"They’re also pushing databases beyond what they are capable of. Amazon.com E-Bay does not maintain integrity constraints in the database – they’re maintained at the application layer. They don’t maintain indexes in the databases; instead lookups are done in Berkeley DB indices since lookup speeds are an order of magnitude faster there than on a relational database. Effectively, Amazon E-Bay is using their expensive database system as a transactional file system!"
Note: Amazon has been changed to E-Bay per the information from Werner himself in the comments of this post. Check out his post on How Databases Used at Big Customers for more info...